Lee, a man who awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee and quickly annoys the doctors treating them both by insisting that Lee has “locked-in” syndrome. After House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to “unlock” him. Meanwhile, Wilson suspects House is hiding something when he refuses to divulge why he was in New York.